CUSHING SYNDROME

 

Cushing syndrome / disease :- 

Definition :-

This is a disease in which the cortisol level will increase , there are two types of cushing we can say , one is pituitary dependent , another is pituitary independent .

Causes :-  

• One of the main cause is the tumour on pituitary or some medications which had some side affects , among which the main side affect was increase in cortisol .

Symptoms / Characteristics :-

 

• Rounded face 
• Centripital obesity
• Purple coloured stria ( on stomach and near the shoulders and armpits )
• Acne
• Hirutism - increased fascial hair
• Thin and weak legs 
• Little psycotic behaviour
• Dcereased immunity
• Bruises 
• Osteoporosis
• Decreased wound healing capacity 
• Increased bp
• Increased 
• Women may have more hair on the body and irregular periods 

Diagnosis :- 

• Increased cortisol levels in the blood 
• MRI - for testing of presence of tumour
• CT scan - to test presence of tumour
• Ultrasound - to test presence of tumour

Treatment :-

• Transspenoidal microademectomy 
• Bilateral total adrenolectomy
• Pituitary radiation
• Drugs

 

Complication :-